After getting her PhD in Chemistry from the University of Vienna in 2003, Martina Marchetti-Deschmann worked as an assistant at TU Wien and did research stays at the University of Münster (Germany), AMOLF (Netherlands), Leiden Medical Centre (Netherlands), the Czech Academy of Sciences (Czech Republic), and Vanderbilt University (United States). She started to establish omics technologies at TU Wien in 2003 for both industry and basic medical and biological research. She is and has been active in many professional societies to advance mass spectrometric research, education and professionalization. Since her habilitation in 2013, she has dedicated her work to imaging mass spectrometry, which allows the spatial distribution of molecules on surfaces and in tissue to be visualised. Today, she is known worldwide for her correlative, multimodal imaging approaches, in which she combines various imaging methods with mass spectrometry.

In 2025 she was appointed as vice rector for Research, International Affairs and Sustainability at the University of Vetrinary Medicine in Vienna where topics like animal health as well as preventive veterinary medicine, public health and food safety are of interests for human, animal and environmental health.