This talk is devoted to outlining industry and academic developments in supply chain digital twins and resilience. We will discuss adaptation-based principles of supply chain resilience and viability, the design and implementation of digital twins in supply chains, human-AI collaboration for resilience and supply chain stress testing, and the role of data spaces and ecosystems in the design and adaptation of digital twins and resilience models. Pilot implementations will be illustrated using anyLogistix supply chain simulation and optimization software and some use cases in the industry.